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DTSTAMP:20260830T010417Z
UID:850bd5d9-32ac-471d-9db4-41b98b978ec0
DTSTART:20230323T090000Z
DTEND:20230323T170000Z
DESCRIPTION:Rheumatoid arthritis (RA) is a complex\, systemic autoimmune di
 sease that primarily affects the lining of the synovial joints and involve
 s an intricate interplay among genotype and environmental triggers. Early 
 RA starts with the infiltration of the synovial compartment by leukocytes.
  Then\, the synovial fluid is inundated with pro-inflammatory mediators in
 ducing an inflammatory cascade characterised by fibroblast-like synoviocyt
 es (FLS) interactions with cells of the innate and adaptive immune system.
  Cytokines are key mediators\, whereas drugs inhibiting these cytokines le
 ad to RA therapies. Unfortunately\, 40% of patients fail to respond to the
 rapy.\n\nRecently\, many studies have shown that RA FLS activation and the
  subsequent joint damage they perpetuate are associated with an altered me
 tabolism that may be therapeutically targetable.Thus\, RA FLS-directed the
 rapies could become a complementary approach to immune-directed therapies.
 \n\nI will present our efforts to construct a virtual RA FLS and develop a
  computational method to simulate large-scale coupled logical and metaboli
 c models using Boolean and constraint-based modelling. The digital RA FLS 
 can be used to predict intervention points for minimising the sustained in
 flammation\, bone erosion\, and cartilage destruction and identify druggab
 le metabolic switches that could help us reprogram these cells to acquire 
 an anti-inflammatory phenotype.\n\n### About the speaker\n\nDr. Anna Niara
 kis is an Associate Professor\, HDR at UEVE\, Paris-Saclay\, affiliated wi
 th GenHotel\, [European Research Laboratory for Rheumatoid Arthritis](htt
 ps://www.eular.org/en_GB)\, Genopole. She holds a 3-year delegation for re
 search at INRIA\, in the group Lifeware. She has a broad scientific backgr
 ound in Biochemistry\, Biology\, and Pharmaceutical Technology and post-do
 ctoral studies in Computational Systems Biology &amp\; Bioinformatics with
  expertise in complex human diseases. She is a co-leader of the Disease Ma
 ps consortium\, an active member of [CoLoMoTo](http://www.colomoto.org/)
  (Consortium for Logical Modelling Tools)\, and a former coordinator of S
 ysMod (Systems Modelling). 
LOCATION:\, 
SUMMARY:Development of a virtual Rheumatoid Arthritis synovial fibroblast f
 or large-scale dynamic analysis and efficient drug-target identification
URL;VALUE=URI:https://www.ebi.ac.uk/training/events/development-virtual-rhe
 umatoid-arthritis-synovial-fibroblast-large-scale-dynamic-analysis-and
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