Whole genome sequencing (WGS) has been revolutionized by the development of long-read sequencing technologies in the last few years. Driven in no small part by Oxford Nanopore technologies (https://nanoporetech.com/) and Pacific Biosciences, HiFi (https://www.pacb.com/technology/hifi-sequencing/), we now have the ability to sequence long (mb+) single-molecule DNA fragments. Although these developments are expected to alleviate numerous computational challenges surrounding genome analysis they also bring some interesting bioinformatics challenges to which we have to adapt in order to get the most from this powerful technology.

This exciting course aims to introduce the principles and practice using long-read data analysis with a focus on Oxford Nanopore data. We will present the cutting-edge software and best practices tried and tested by our expert bioinformaticians here at Edinburgh Genomics.