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DTSTAMP:20260702T171538Z
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DTSTART:20260901T120000Z
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DESCRIPTION:A free pre-conference tutorial organized by Young InfoLife in c
 ollaboration with CIBB 2026\, the 21st International Conference on Computa
 tional Intelligence Methods for Bioinformatics and Biostatistics.\n\nThe r
 everse engineering of biological networks from omics data is one of the ce
 ntral problems in systems biology and bioinformatics. In particular\, the 
 inference of gene regulatory networks (GRNs) from transcriptomic data invo
 lves reconstructing plausible regulatory relationships between genes from 
 indirect measures of gene expression\, obtained using technologies such as
  RNA-seq.\n\nThis problem is particularly relevant but also complex: trans
 criptomic datasets are often noisy\, high-dimensional\, and characterised 
 by a number of genes far exceeding the number of available samples. The co
 rrect interpretation of the results requires a combination of biological\,
  statistical\, and computational expertise.\n\nThis tutorial guides partic
 ipants through a complete reverse-engineering workflow\, from data prepara
 tion to network evaluation\, with an introductory and practical approach a
 ccessible also to those without prior experience in biological network inf
 erence.\n\n**Topics covered:**\n\n- biological and computational backgroun
 d of gene regulatory networks\n- data inspection\, normalization\, transfo
 rmation\, gene filtering\, exploratory analysis\n- computational methods f
 or regulatory network inference: correlation-based\, mutual information-ba
 sed\, and regression-based approaches\n- network evaluation: precision\, r
 ecall\, AUROC\, AUPRC\, and the limitations of accuracy in sparse biologic
 al networks\n- critical interpretation of inferred regulatory interactions
 \n\n**Speakers:**\n\n- Dora Tortarolo\, Università degli Studi di Torino\
 n- Grete Francesca Privitera\, Università degli Studi di Catania\n- Rober
 to Pagliarini\, Università degli Studi di Udine\n\n**Materials:** all mat
 erials required to follow the tutorial and reproduce the analysis are prov
 ided\, including slides\, example transcriptomic datasets\, scripts/notebo
 oks for preprocessing and inference\, step-by-step instructions\, and refe
 rence networks. Recordings of preparatory webinars are made available on t
 he Young InfoLife YouTube channel.\n\nThe event is part of CIBB 2026\, tak
 ing place at Sapienza University of Rome on September 2-4\, 2026.\n\nConfe
 rence website: https://cibb2026.teralab.ai
LOCATION:Piazzale Aldo Moro\, 5\, 5 Piazzale Aldo Moro
SUMMARY:Tutorial on Reverse Engineering of Gene Regulatory Networks
URL;VALUE=URI:https://cibb2026.teralab.ai/satellite-events/reverse-engineer
 ing-gene-regulatory-networks/
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